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      • ESR1 Rita Marreiros
      • ESR2 Daniela Moutinho
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      • ESR4 Marion Bonneau
      • ESR5 Miguel Ángel González Lozano
      • ESR6 Martina Rosato
      • ESR7 Benedetta Fazari
      • ESR8 Karola Käfer
      • ESR9 Elena Marchisella
      • ESR10 Marcello Venzi
      • ESR11 Vishal Sinha
      • ESR12 David Just
      • ESR13 Nirmal Raman Kannaiyan
      • ESR14 Tarik Dahoun
      • ESR15 Yogesh Paudel
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ESR1 Rita Marreiros

ESR-1-Rita-Marreiros-grootSupervisor: Carsten Korth
Department of Neuropathology, Heinrich Heine University, Düsseldorf , Germany

My master studies were done at University of Coimbra, in Portugal, where I the master in cellular and molecular biology, with specialization in neurosciences. In the second year of my Master, I performed my master thesis at Janssen Pharmaceutica, in Belgium, where I optimized an in vitro Tau seeding and aggregation model, with the objective of creating a platform to study pathological mechanisms that occur in Alzheimer’s disease, and that are associated with aggregation of Tau protein.

As part of In-SENS training network I am a PhD student working in the ESR1 project, and my focus will be the interactions and functions of Disrupted in schizophrenia-1 (DISC1) protein in mental disorders. Previous results from our group demonstrated that DISC1 form insoluble protein aggregates in a similar fashion of diseases characterized by protein aggregation, e.g.Tauopathies, and synucleopathies, among others.

According with this I am mainly interested in the effect of DISC1 aggregation on the interaction of this protein, leading to a loss or gain of molecular interactions in mental disorders. The main work of this project will be performed in a transgenic animal and also in cell lines. This project will include a variety of cellular and molecular techniques that can elucidate the molecular mechanisms of DISC1 aggregation pathways in these diseases.

Groundbreaking: DISC1opathies

A novel subgroup of CMD diseases

evelyn.van.royen@sylics.com | T +31 20 598 28 06 | M +31 6 46 06 46 05
This project is funded by the EC under FP7-PEOPLE-2013 (607616)

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