Supervisor: Prof. Guus Smit
Department of Molecular and Cellular Neurobiology, CNCR, VU Amsterdam, Netherlands.
I am from Spain. I did the Biochemistry Degree at the Complutense University of Madrid and I continued my studies with the Master in Neuroscience from Autonomous University of Madrid.
As part of the IN-SENS program, my project is focused on the proteomic analysis of synaptic proteins and complexes that play a role in aberrant synaptic signaling in schizophrenia. We will start with the identification, quantification and characterization of synaptic proteins and complexes dysregulated in synapses of different SCZ mouse models. It will be based on mass spectrometric interaction proteomics and involves a wide spectrum of biochemical analysis techniques. In addition, another aim of this project is the determination of protein interactors that may form important signaling nodes in schizophrenia, in order to explore the shifts in activity-dependent composition of protein complexes (interactome) in cortical synapses of wildtype mice and disease mouse models. The information obtained will be employ as well to provide a comparative analysis of synaptic protein expression levels with data of other animal models of brain disease. Finally, these will be complemented by functional analysis in neuronal cultures in vitro (cellomics) to investigate the interactome cellular